| 12 January 2022

Jessica Delboni, Alesha Zappitella, Ramona Pascual

Invicta FC 45: Zappitella vs. Delboni II is amixed martial arts event headlined by Alesha Zappitella defending her atomweight championship against Jéssica Delboni in a rematch from Invicta FC 44. A bout between Emily Whitmire and Hilarie Rose was scheduled but has since been postponed.